J., Rodriguez-Contreras, A., Trinh, A., Bailey, R. This work is one of the very few experimental studies that causally link dendritic activity in a primary sensory area with a high-level cognitive function, namely sensory perception. Active cortical dendrites modulate perception. General anesthesia decouples cortical pyramidal neurons.
Novel approaches to monitor and manipulate single neurons in vivo. Neue Darstellung vom histologischen Bau des Centralnervensystems. Reprinted in: On the fine structure of the pes Hippocampi major (with plates XIII–XXIII). Sulla Fina Anatomia Degli Organi Centrali del Sistema Nervoso. This Review features the most important, to our understanding, contributions of modelling of dendritic computations, including those pending experimental verification, and highlights studies of successful interactions between the modelling and experimental neuroscience communities. Validation of modelling predictions often requires - and drives - new technological advances, thus closing the loop with theory-driven experimentation that moves the field forward. Since then, modelling of dendrites has been instrumental in driving neuroscience research in a targeted manner, providing experimentally testable predictions that range from the subcellular level to the systems level, and their relevance extends to fields beyond neuroscience, such as machine learning and artificial intelligence. Theoretical work in the 1960s predicted important dendritic effects on neuronal processing, establishing computational modelling as a powerful technique for their investigation. Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal to the beautiful recordings of today, neuroscientists have been striving to unravel the mysteries of these structures.
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